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Reference type: Journal
Authors: Zaidi SA, Lee SM, Cheong WJ
Article Title: Open tubular capillary columns with basic templates made by the generalized preparation protocol in capillary electrochromatography chiral separation and template structural effects on chiral separation capability.
Publication date: 2011
Journal: Journal of Chromatography A
Volume: 1218
Issue: (9)
Page numbers: 1291-1299.
DOI: 10.1016/j.chroma.2010.12.117
Alternative URL: http://www.sciencedirect.com/science/article/B6TG8-51WD0JJ-4/2/a02f16a888d607f0d8ecb8b59c7207e9

Abstract: Some open tubular (OT) molecule imprinted polymer (MIP) silica capillary columns have been prepared using atenolol, sulpiride, methyl benzylamine (MBA) and (1-naphthyl)-ethylamine (NEA) as templates by the pre-established generalized preparation protocol. The four MIP thin layers of different templates showed quite different morphologies. The racemic selectivity of each MIP column for the template enantiomers was optimized by changing eluent composition and pH. The template structural effects on chiral separation performance have been examined. This work verifies the versatility of the generalized preparation protocol for OT-MIP silica capillary columns by extending its boundary toward templates with basic functional group moieties. This study is the very first report to demonstrate a generalized MIP preparation protocol that is valid for both acidic and basic templates. The chiral separation performances of atenolol and sulpiride by the MIPs of this study were found better than or comparable to those of atenolol and sulpiride obtained by non-MIP separation techniques and those of some basic template enantiomers obtained by MIP based techniques
Template and target information: atenolol, sulpiride, methyl benzylamine, MBA, (1-naphthyl)-ethylamine, NEA
Author keywords: molecule imprinted polymer, Basic templates, OT-CEC, chiral separation, Template structural effects


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