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Reference type: Journal
Authors: Esfandyari-Manesh M, Javanbakht M, Atyabi F, Badiei A, Dinarvand R
Article Title: Effect of porogenic solvent on the morphology, recognition and release properties of carbamazepine-molecularly imprinted polymer nanospheres.
Publication date: 2011
Journal: Journal of Applied Polymer Science
Volume: 121
Issue: (2)
Page numbers: 1118-1126.
DOI: 10.1002/app.33812

Abstract: Abstract: This study focus on the effect of the porogenic solvent on the morphology, recognition, and drug release of carbamazepine-molecularly imprinted polymer nanospheres prepared by precipitation polymerization. The scanning electron microscopy (SEM) images and Brunauer-Emmett-Teller (BET) analysis showed that molecularly imprinted polymer (MIP) prepared by acetonitrile exhibited a regular spherical shape at the nanoscale with a high degree of monodispersity, specific surface area of 242 m2 g -1, and pore volume of 1 mL g -1, while those using chloroform and toluene produced irregular polymer particles with low specific surface area and pore volume. MIP prepared by acetonitrile/chloroform (1 : 1, v/v) showed mediator texture properties compared to MIPs obtained by acetonitrile or chloroform. Results from saturation and displacement assays indicated that the imprinted nanospheres with binding capacity of 2.85 (mg CBZ/g polymer) had high specific affinity to CBZ in contrast to nonimprinted nanospheres (1.63 mg CBZ/g polymer). The imprinted nanospheres with 2.4 selectivity factor had good recognition to CBZ than analog template of oxcarbazepine. Moreover, release studies showed that 20% of loaded CBZ was released from the imprinted nanospheres within the initial 6 h, while another 80% of CBZ was released in the following 9 days. 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Template and target information: carbamazepine
Author keywords: molecular imprinting, Nanospheres, porogen effects, morphology, Drug release


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