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Reference type: Journal
Authors: Jin GY, Zhang BF, Tang YW, Zuo XJ, Wang SC, Tang JY
Article Title: Imprinted functionalized silica sol-gel for solid-phase extraction of triazolamin.
Publication date: 2011
Journal: Talanta
Volume: 84
Issue: (3)
Page numbers: 644-650.
DOI: 10.1016/j.talanta.2011.01.035
Alternative URL: http://www.sciencedirect.com/science/article/B6THP-520TJKK-6/2/3a8a1442b8d8e16d95597acf217f5868

Abstract: A triazolam-imprinted silica microsphere was prepared by combining a surface molecular-imprinting technique with the sol-gel process. The results illustrate that the triazolam-imprinted silica microspheres provided using γ-aminopropyltriethoxysilane and phenyltrimethoxysilane as monomers exhibited higher selectivity than those provided from γ-aminopropyltriethoxysilane and methyltriethoxysilane. In addition, the optimum affinity occurred when the molar ratio of γ-aminopropyltriethoxysilane, phenyltrimethoxysilane, and the template molecule was 4.2:4.7:0.6. Retention factor (k) and imprinting factor (IF) of triazolam on the imprinted and non-imprinted silica microsphere columns were characterized using high performance liquid chromatography (HPLC) with different mobile phases including methanol, acetonitrile, and water solutions. The molecular selectivity of the imprinted silica microspheres was also evaluated for triazolam and its analogue compounds in various mobile phases. The better results indicated that k and IF of triazolam on the imprinted silica microsphere column were 2.1 and 35, respectively, when using methanol/water (1/1, v/v) as the mobile phase. Finally, the imprinted silica was applied as a sorbent in solid-phase extraction (SPE), to selectively extract triazolam and its metabolite, α-hydroxytriazolam, from human urine samples. The limits of detection (LOD) for triazolam and α-hydroxytriazolam in urine samples were 30 0.21 ng mL-1 and 33 0.26 ng mL-1, respectively
Template and target information: triazolam
Author keywords: surface imprinting, Solid-phase extraction, Triazolam, Metabolite, Urine sample

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