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Reference type: Journal
Authors: Yin XY, Liu QS, Jiang YF, Luo YM
Article Title: Development of andrographolide molecularly imprinted polymer for solid-phase extraction.
Publication date: 2011
Journal: Spectrochimica Acta Part A-Molecular and Biomolecular Spctroscopy
Volume: 79
Issue: (1)
Page numbers: 191-196.
DOI: 10.1016/j.saa.2011.02.034
Alternative URL: http://www.sciencedirect.com/science/article/B6VNG-527PRVJ-5/2/ec72554f4e5ec355ba3f12a6687c0985

Abstract: A method employing molecularly imprinted polymer (MIP) as selective sorbent for solid-phase extraction (SPE) to pretreat samples was developed. The polymers were prepared by precipitation polymerization with andrographolide as template molecule. The structure of MIP was characterized and its static adsorption capacity was measured by the Scatchard equation. In comparison with C18-SPE and non-imprinted polymer (NIP) SPE column, MIP-SPE column displays high selectivity and good affinity for andrographolide and dehydroandrographolide for extract of herb Andrographis paniculata (Burm.f.) Nees (APN). MIP-SPE column capacity was 11.9 0.6 μmol/g and 12.1 0.5 μmol/g for andrographolide and dehydroandrographolide, respectively and was 2-3 times higher than that of other two columns. The precision and accuracy of the method developed were satisfactory with recoveries between 96.4% and 103.8% (RSD 3.1-4.3%, n = 5) and 96.0% and 104.2% (RSD 2.9-3.7%, n = 5) for andrographolide and dehydroandrographolide, respectively. Various real samples were employed to confirm the feasibility of method. This developed method demonstrates the potential of molecularly imprinted solid phase extraction for rapid, selective, and effective sample pretreatment
Template and target information: andrographolide, dehydroandrographolide
Author keywords: molecularly imprinted polymer, solid phase extraction, Andrographolide, selective adsorption


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