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Reference type: Journal
Authors: Gong XY, Cao XJ
Article Title: Preparation of molecularly imprinted polymers for artemisinin based on the surfaces of silica gel.
Publication date: 2011
Journal: Journal of Biotechnology
Volume: 153
Issue: (1-2)
Page numbers: 8-14.
DOI: 10.1016/j.jbiotec.2011.02.005
Alternative URL: http://www.sciencedirect.com/science/article/B6T3C-5281SCH-1/2/36a0086b49fbec384d68ab914ac8438e

Abstract: Artemisinin is an effective antimalarial drug isolated from the herbal medicine Artemisia annua L. Molecular imprinting is a technique of preparing molecularly imprinted polymers (MIPs) which can specifically recognize the imprinted template molecules. In this work, silica gel were used as supporting matrix, and vinyltriethoxysilane (VTES) was grafted onto its surface. The preparation of MIPs for artemisinin was performed on the surfaces of the modified silica gel using artemisinin as the template, acrylamide (AM) and methacrylic acid (MAA) as the functional monomers, ethylene glycol dimethacrylate (EGDMA) as the cross-linker and 2,2'-azo-bis-isobutyronitrile (AIBN) as the initiator. Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR) and pore size analysis were used to characterize the prepared MIPs. The adsorption kinetic curve, adsorption isotherm and selective adsorption were measured by static method. The adsorption reached equilibrium at about 10áh, while fast adsorption took place during the first 2-3 h. The maximum adsorption capacity has been found to be 37.13 mg/g according to calculation with Langmuir-Freundlich isotherm. The electivity coefficients of MIPs for artemisinin with respect to artemether and arteether were 2.88 and 3.38, respectively. The results showed that the MIPs possessed good specific adsorption capacity and selectivity for artemisinin
Template and target information: artemisinin
Author keywords: Artemisinin, surface molecularly imprinted polymers, silica gel


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