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Reference type: Book Chapter
Authors: Arnold FH, Striegler S, Sundaresan V
Publication date: 1998
Chapter title: Chiral ligand exchange adsorbents for amines and underivatized amino acids: "bait-and-switch" molecular imprinting.
Chapter number: 7
Page numbers: 109-118.
DOI: 10.1021/bk-1998-0703.ch007

Book title: Molecular and Ionic Recognition with Imprinted Polymers
Editors: Bartsch RA, Maeda M
Publisher: The American Chemical Society
City: Washington DC
Series title: ACS Symposium Series
Volume number: 703

Abstract: Ligand-exchange adsorbents for the chiral separation of underivatized a-amino acids and amine analogs have been prepared by molecular imprinting with a polymerizable copper complex and the amino acid as template. Because the complexation equilibria in these mixed-ligand systems involve numerous species, it is extremely important to characterize the template:monomer assemblies prior to polymerization. Isothermal titration calorimetry and classical species distribution diagrams have been used to determine the conditions under which the amino acids (phenylalanine) form strong 1:1 mixed-ligand complexes with the copper-iminodiacetate (CuIDA) functional monomer. In contrast, a diamine template ethylenediamine does not form 1:1 complexes with CuIDA; the diamine instead competes with IDA for the metal ion, and a stronger chelating group is required. Adsorbents prepared using enantiomers of phenylalanine as template show enantioselectivity for phenylalanine and tyrosine as well as for a chiral amine analog of phenylalanine, a-methylphenethylamine. The use of the amino acid as the template in this 'bait-and-switch' imprinting approach allows creation of chirally selective binding sites suitable for separations of chiral amines


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