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Reference type: Journal
Authors: Markowitz MA, Kust PR, Deng G, Schoen PE, Dordick JS, Clark DS, Gaber BP
Article Title: Catalytic silica particles via template-directed molecular imprinting.
Publication date: 2000
Journal: Langmuir
Volume: 16
Issue: (4)
Page numbers: 1759-1765.
DOI: 10.1021/la990809t

Abstract: The surfaces of silica particles were molecularly imprinted with an alpha-chymotrypsin transition-state analogue (TSA) by utilizing the technique of template-directed synthesis of mineralized materials. The resulting catalytic particles hydrolyzed amides in an enantioselective manner. A mixture of a nonionic surfactant and the acylated chymotrypsin TSA, with the TSA acting as the headgroup at the surfactant-water interface, was used to form a microemulsion for silica particle formation. Incorporation of amine-, dihydroimidazole- , and carboxylate-terminated trialkoxysilanes into the particles during imprinting resulted in enhancement of the rates of amide hydrolysis. Acylated imprint molecules formed more effective imprints in the presence of the functionalized silanes than noplacylated imprint molecules. Particles surface-imprinted with the chymotrypsin TSA were selective for the trypsin substrate, and particles surface- imprinted with the L-isomer of the enzyme TSA were enantioselective for the D-isomer of the substrate

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