MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Anirudhan TS, Sandeep S
Article Title: Synthesis and characterization of molecularly imprinted polymer of N-maleoylchitosan-grafted-2-acrylamido-2-methylpropanesulfonic acid and its controlled delivery and recognition of bovine serum albumin.
Publication date: 2011
Journal: Polymer Chemistry
Volume: 2
Issue: (9)
Page numbers: 2052-2061.
DOI: 10.1039/C1PY00059D

Abstract: In this study a novel molecularly imprinted polymer matrix, namely protein-imprinted N-maleoylchitosan-grafted-2-acrylamido-2-methylpropanesulfonic acid polymer (MIP) matrix was prepared by using bovine serum albumin (BSA) as a template. The characteristics of the MIP were investigated using FTIR, SEM, XRD and Zeta Potential Analyses. The effects of monomer to template ratio, cross linking density, porogen, pH and ionic strength on the loading of BSA into the MIP were investigated. The adsorption studies showed that the MIP exhibits good recognition for BSA, as compared to non-imprinted polymer (NIP). The experimental adsorption isotherms of BSA onto MIP and NIP were determined and well fitted by Sips model with a maximum binding capacity of 113.51 mg g-1 for MIP and 76.39 mg g-1 for NIP. A pseudo-second-order kinetic model adequately described the kinetic rate in comparison to a pseudo-first-order model. In vitro release profiles of model drug from the MIP were investigated in physiological buffered solution using a UV/vis spectrophotometer. In addition, the drug release mechanism was analyzed by fitting the amount of drug released into Peppa's potential equation
Template and target information: protein, bovine serum albumin, BSA


  mipdatabase.com logo special offer joke shirt  Lab Hunk Periodic shirt  HE-MAN polymer chemistry shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner