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Abstract: A synthetic polymer selective to Hydrochlorothiazide was prepared by a non-covalently imprinted technique,using Hydrochlorothiazide as a template,methyl methacrylate as a functional monomer and tri-[hydroxymethyl]-propan-tri-acrylic acid as a cross-linker,and methanol as a porogenic solvent.After extraction of template,affinity of the polymer imprinted with Hydrochlorothiazide was examined in re-binding experiment.From the Scatchard analysis,binding site heterogeneity is obvious and two types of binding sites can be identified.The equilibrium dissociation constant Kd1,the apparent maximum amount Qmax1 and the binding constant Ka1 of the higher affinity binding sites can be calculated to be 57.0 μmol/L,5.59 μmol/g,and 1.75×10 4 (mol/L)-1;while Kd2,Qmax2,and Ka2 of the lower affinity binding sites were calculated to be 3.96 mmol/L, 216.4 μmol/g and 2.53 × 10 2 (mol/L)-1,respectively.
Template and target information: Hydrochlorothiazide
Author keywords: hydrochlorothiazide, molecularly imprinted polymer, imprinting condition