MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Gomez-Caballero A, Guerreiro A, Karim K, Piletsky S, Goicolea MA, Barrio RJ
Article Title: Chiral imprinted polymers as enantiospecific coatings of stir bar sorptive extraction devices.
Publication date: 2011
Journal: Biosensors and Bioelectronics
Volume: 28
Issue: (1)
Page numbers: 25-32.
DOI: 10.1016/j.bios.2011.06.048
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0956566311004799

Abstract: This paper reports the design of Molecularly Imprinted Polymers (MIP) with affinity towards (S)-citalopram using computational modeling for the selection of functional monomers and monomer:template ratio. Acrylamide was selected as functional monomer and the final complex functional monomer/template resulted in a 3:1 ratio. The polymer was synthesized by radical polymerization initiated by UV onto magnetic stir-bars in order to obtain a stir bar sorptive extraction (SBSE) device capable of selective enantiomeric recognition. After successful template removal, the parameters affecting the SBSE procedure (sample volume, ionic strength, extraction time and pH) were optimized for the effective rebinding of the target analyte. The resultant chirally imprinted polymer based stir-bar was able to selectively extract (S)-citalopram from a racemic mixture in an aqueous media with high specificity (specificity factor 4) between 25 and 500 μg L-1. The MIP coated stir-bars can have significance for enantiospecific sample pre-concentration and subsequent analysis without the need for any chiral chromatographic separation
Template and target information:
Author keywords: MIPs, chirality, Citalopram, SBSE

  Shirt featuring the name Sergey spelled out in symbols of the chemical elements  Mug featuring the name Kal spelled out in the single letter amino acid code  Chemists are fun customisable shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner