Authors: Matsui J
, Kaneko A
, Miyoshi Y
, Yokoyama K
, Tamiya E
, Takeuchi T
A molecularly imprinted nicotine-selective polymer.
Publication date: 1996
Journal: Analytical Letters
Alternative URL: http://www.informaworld.com/10.1080/00032719608002231
Abstract: A (-)-nicotine-selective polymer was prepared by molecular imprinting technique using methacrylic acid as a functional monomer. Liquid- chromatographic tests, using the polymers as a stationary phase, exhibited that the basicity of the functional group of (-)-nicotine is crucial for rebinding by the molecularly imprinted polymer. Scatchard analysis implied that tile binding sites generated within the polymer are heterogeneous in terms of affinity, and the apparent dissociation constant of the highest affinity binding sites was estimated as 3.7 mu M
Template and target information: nicotine
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