MIPdatabase
Authors: Xu L, He JF, Liu L, Deng QY
Article Title: Preparation and Chromatographic Characteristic of Molecularly Imprinted Chiral Stationary Phase with Dansyl-L-phenylalanine as Template.
Publication date: 2005
Journal: Chinese Journal of Pharmaceutical Analysis
Volume: 25
Issue: (11)
Page numbers: 1309-1311.
Alternative URL: http://en.cnki.com.cn/Article_en/CJFDTotal-YWFX200511006.htm
Abstract: Objective:To establish a method to separate enantiomers with thin-layer plates made by molecularly imprinted chiral stationary phase.Methods:MIPs were synthesized using Dns-L-phe as a template,MAA or MAA+2-Vpy as monomers,respectively.The molecularly imprinted thin-layer plates were prepared by mixing the polymer with the binding agent(2CaSO_4·H_2O).Optimum of the mobile phase, Resolution of Dns-DL-phe was researched on the thin-layer plates.Results:Dns-DL-phe was separated completely on the two kinds of plates.The separation factor was 1.7 and 2.2 respectively,and the better resolution was achieved on plates made by double monomers when the mobile phase was acetonitrile and acetic acid (9.9:0.1).Conclusion:The method of fers a rapid,sensitive and reliable method to separate enantiomers.
Template and target information: dansyl-l-phenylalanine, Dns-L-Phe
Author keywords: molecularly imprinted polymer, dansyl-L-phenylalanine (Dns-DL-phe), Bulk polymerization, TLC, chiral separation
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