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Reference type: Journal
Authors: Matsui J, Nicholls IA, Takeuchi T
Article Title: Highly stereoselective molecularly imprinted polymer synthetic receptors for cinchona alkaloids.
Publication date: 1996
Journal: Tetrahedron: Asymmetry
Volume: 7
Page numbers: 1357-1361.

Abstract: Molecularly imprinted polymer (MIP) receptors for the cinchona alkaloids (-)-cinchonidine 1 and (+)-cinchonine 2 have been prepared and characterised using the polymers as HPLC chiral stationary phases(CSPs). Stereoseparation factors of up to 31 were obtained. The resolution of the beta-adrenergic blocking agent propranolol 8 and studies with related structures of pharmaceutical significance has permitted conclusions to be drawn regarding the origin of recognition phenomena. Copyright (C) 1996 Elsevier Science


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