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Reference type: Journal
Authors: Tse Sum Bui B, Haupt K
Article Title: Preparation and evaluation of a molecularly imprinted polymer for the selective recognition of testosterone - application to molecularly imprinted sorbent assays.
Publication date: 2011
Journal: Journal of Molecular Recognition
Volume: 24
Issue: (6)
Page numbers: 1123-1129.
DOI: 10.1002/jmr.1162

Abstract: Biomimetic testosterone receptors were synthesized via molecular imprinting for use as antibody mimics in immunoassays. As evaluated by radioligand binding assays, imprinted polymers prepared in acetonitrile were very specific for testosterone because the nonimprinted control polymers bound virtually no radiolabeled testosterone. The polymers present an appreciable affinity, with association constants of Ka = 3.3 x 10 7 M-1 (high-affinity binding sites). The binding characteristics of the polymers were also evaluated in aqueous environment to study their viabilities as alternatives to antibodies in molecularly imprinted sorbent assays. Compared with the testosterone-specific antibodies present in commercial kits, our molecularly imprinted polymers are somewhat less sensitive but show a high selectivity. Copyright 2011 John Wiley & Sons, Ltd
Template and target information: testosterone
Author keywords: molecularly imprinted polymer, immunoassay, testosterone


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