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Reference type: Journal
Authors: Huang MX, Pang WS, Zhang J, Lin SD, Hu J
Article Title: A target analogue imprinted polymer for the recognition of antiplatelet active ingredients in Radix Salviae Miltiorrhizae by LC/MS/MS.
Publication date: 2012
Journal: Journal of Pharmaceutical and Biomedical Analysis
Volume: 58
Issue: (1)
Page numbers: 12-18.
DOI: 10.1016/j.jpba.2011.09.010
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0731708511005280

Abstract: The purpose of this study was to prepare a propyl gallate (PrG) molecular imprinted polymer as a cartridge stuffing material to isolate antiplatelet active ingredients. A macroporous polymer was synthesized utilizing ethylene glycol dimethacrylate (EDMA) as the crosslinking agent, PrG as the template molecule and 4-vinylpyridine (4-Vpy) as the functional monomer. Subsequently, PrG was removed by washing with methanol-glacial acetic acid (9:1, v/v). The molecular imprinted polymer recognized an active ingredient, protocatechuic acid, from a crude extract of the Chinese herbal medicine, Radix Salviae Miltiorrhizae (Danshen), using an on-line column switching solid phase extraction process. Pharmacological experiments showed that protocatechuic acid inhibits arachidonic acid (10 mg/kg) induced aggregation of rat platelets in vivo. This study provides an example of an application of separation-analysis technique for screening potentially bioactive compounds
Template and target information: propyl gallate, PrG, antiplatelet active ingredients, protocatechuic acid
Author keywords: Propyl gallate, molecular imprinted polymer, On-line extraction, LC, MS, MS, Antiplatelet ingredient, Recognition

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