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Reference type: Journal
Authors: Guo ZY, Hao TT, Shi LL, Gai PP, Duan J, Wang S, Gan N
Article Title: A highly sensitive electrochemiluminescence method combined with molecularly imprinted solid phase extraction for the determination of phenolphthalein in drug, slimming food and human plasma.
Publication date: 2012
Journal: Food Chemistry
Volume: 132
Issue: (2)
Page numbers: 1092-1097.
DOI: 10.1016/j.foodchem.2011.11.056
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0308814611016384

Abstract: An electrochemiluminescence (ECL) inhibition method combined with molecularly imprinted solid phase extraction (MISPE) was developed for quantitative determination of phenolphthalein in drug, slimming food and human plasma. Phenolphthalein could strongly inhibit the ECL signal of Ru(bpy) 3 2 + /2-(dibutylamino)ethanol (DBAE) system that was used as the basis of the analysis. Molecularly imprinted polymers (MIPs) were synthesized as solid phase extraction (SPE) sorbents, and MISPE protocol was developed for the selective extraction and purification of phenolphthalein. Under the optimized conditions, quenched ECL intensity versus the logarithm of the concentration of phenolphthalein was in good linear relationship over a concentration range from 3.18 x 10-10 to 1.59 x 10-7 g/mL and the detection limit was 1.0 x 10-10 g/mL. High affinity and selectivity of MISPE enabled the successful application of this method to determine phenolphthalein in drug, slimming food and human plasma. Further, a possible mechanism for the quenching effects of Ru(bpy) 3 2 + /DBAE system by phenolphthalein was also proposed
Template and target information: phenolphthalein
Author keywords: determination, Electrochemiluminescence, inhibition, phenolphthalein, Ru(bpy) 3 2 + , DBAE system, Slimming food


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