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Reference type: Book Chapter
Authors: Lord H, Bojko B
Publication date: 2012
Chapter title: Drug Analysis by SPME.
Chapter number: 10
Page numbers: 335-382.
DOI: 10.1016/B978-0-12-416017-0.00010-3

Book title: Handbook of Solid Phase Microextraction
Editors: Pawliszyn J
Publisher: Elsevier
City: Oxford
ISBN: 978-0-12-416017-0

Abstract: The investigation of solid-phase microextraction (SPME) technology for the analysis of drugs has been pursued since the inception of the technique, driven by simplicity of the extraction process. There has been significant advance in the application of SPME technology to therapeutic pharmaceutical compounds and drugs that can be abused based on headspace and direct extraction. Much of this advance has come from innovation in sorbent and instrument design and configuration. Such approaches as ion exchange coatings, liquid crystalline films, Carbowax®, metal rods to electorodeposit analytes, pencil "leads", nafion, polypyrrole, restricted access materials and immunoaffinity materials are explored in this chapter. In addition to fibres for gas chromatography applications, blades are used as a sample preparation before liquid chromatography determinations. The applications exploiting these innovations are still preliminary or at the proof-of-concept phase. None have achieved wide acceptance or broad application yet, despite the appeal of the SPME format. A key aspect in the regulatory control of pharmaceutical products is monitoring for impurities in these products, an application that is well suited for SPME technology. Keywords Biological fluids, tissues, forensic, toxicology, optimisation, polar analytes, restricted access materials, sol - gels, monolithic extraction phases, polypyrrole, immunoafinity
Template and target information: Review - drug analysis

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