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Abstract: 4-Vinyl pyridine (4VP) was grafted on micron-sized silica gel particles in a manner of "graft from" in a solution poltmerization system by right of the mediation of the coupling agent 3-methacryloxypropyltrimethoxysilane (MPS),obtaining the grafted functional particles P4VP/SiO2.Subsequently,the molecular imprinting towards the grafted P4VP was conducted with L-Asp that is one enantiomer of aspartic acid (Asp) as template molecule and 1,6-dibromohexane as crosslinking agent by using the novel surface-molecular imprinting technique put forward and established by our research group,and the L-Asp molecule-imprinted material MIP-P4VP/SiO2 was prepared.With another enantiomer of aspartic acid,D-Asp,as a contrast compound,both static method and dynamic method were adopted to study the recognition character of MIP-P4VP/SiO2 for L-Asp,and the separation ability of MIP-P4VP/SiO2 towards L-Asp and D-Asp in the raceme was explored.The experiment results show that MIP-P4VP/SiO2 have obvious recognition selectivity and fine binding affinity for L-Asp,and the selectivity coefficient is equal to 3.85 with respect to D-Asp,displaying the fine separation property for the enantiomers of aspartic acid. Besides, MIP-P4VP/SiO2 has excellent elution property,with a diluted aqueous solution of NaOH as the eluent,the desorption ratios of L-Asp reach 98.52% in 12 BV.
Template and target information: L-aspartic acid
Author keywords: aspartic acid, enantiomer separation, Surface-molecular imprinting, 4-Vinyl pyridine, graft polymerization, molecular recognition