MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Guo JF, Gao BJ
Article Title: Studies on realizating chiral separation of enantiomers of aspartic acid by constituting chiral caves with surface-molecular imprinting technique.
Publication date: 2012
Journal: Acta Polymerica Sinica
Issue: (1)
Page numbers: 47-55.
DOI: 10.3724/SP.J.1105.2012.11061
Alternative URL: http://www.gfzxb.org/EN/abstract/abstract13605.shtml

Abstract: 4-Vinyl pyridine (4VP) was grafted on micron-sized silica gel particles in a manner of "graft from" in a solution poltmerization system by right of the mediation of the coupling agent 3-methacryloxypropyltrimethoxysilane (MPS),obtaining the grafted functional particles P4VP/SiO2.Subsequently,the molecular imprinting towards the grafted P4VP was conducted with L-Asp that is one enantiomer of aspartic acid (Asp) as template molecule and 1,6-dibromohexane as crosslinking agent by using the novel surface-molecular imprinting technique put forward and established by our research group,and the L-Asp molecule-imprinted material MIP-P4VP/SiO2 was prepared.With another enantiomer of aspartic acid,D-Asp,as a contrast compound,both static method and dynamic method were adopted to study the recognition character of MIP-P4VP/SiO2 for L-Asp,and the separation ability of MIP-P4VP/SiO2 towards L-Asp and D-Asp in the raceme was explored.The experiment results show that MIP-P4VP/SiO2 have obvious recognition selectivity and fine binding affinity for L-Asp,and the selectivity coefficient is equal to 3.85 with respect to D-Asp,displaying the fine separation property for the enantiomers of aspartic acid. Besides, MIP-P4VP/SiO2 has excellent elution property,with a diluted aqueous solution of NaOH as the eluent,the desorption ratios of L-Asp reach 98.52% in 12 BV.
Template and target information: L-aspartic acid
Author keywords: aspartic acid, enantiomer separation, Surface-molecular imprinting, 4-Vinyl pyridine, graft polymerization, molecular recognition

  MIPs are Forever spoof movie poster bag  Chemistry peptide mug  Chemists are fun customisable shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner