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Reference type: Journal
Authors: Guo JF, Gao BJ, Zhang ZG
Article Title: Realizating chiral separation of enantiomers of glutamic acid with novel surface-molecular imprinting technique.
Publication date: 2011
Journal: Journal of Chemical Industry and Engineering (China)
Volume: 62
Issue: (11)
Page numbers: 3207-3214.
Alternative URL: http://www.hgxb.com.cn/ZH/Magazine/Show.aspx?ID=14348

Abstract: Poly 4-vinyl pyridine/SiO 2 (P4VP/SiO 2), a grafted functional particles, was prepared by grafting 4-vinyl pyridine (4VP) on micro-sized silica gel particles with the "graft from" method, using 3-methacryloxypropyl trimethoxysilane (MPS)as coupling agent. Subsequently, by using the novel surface-molecular imprinting technique, the L-Glu molecule-imprinted material MIP-P4VP/SiO 2 was prepared by imprinting towards the grafted P4VP with L-Glu, one enantiomer of glutamic acid (Glu), as template molecule and 1, 6-dibromohexane as crosslinking agent. The recognition characteristics of MIP-P4VP/SiO 2 for L-Glu was studied by both static method and dynamic method in which D-Glu was used as a contrast compound. The separation ability of MIP-P4VP/SiO 2 towards L-Glu and D-Glu in the racemic solution was examined. The experiment results showed that MIP-P4VP/SiO 2 had obvious recognition selectivity and fine binding affinity for L-Glu, and the selectivity coefficient was equal to 3.38 with respect to D-Glu, displaying the fine separation property for the enantiomers of glutamic acid. Besides, MIP-P4VP/SiO 2 had excellent elution property with diluted aqueous solution of NaOH as eluent, the desorption ratios of L-Glu could reach 99.53% in 12 BV. Moreover, this material showed effective separation ability of repeated use for more than ten times. All Rights Reserved
Template and target information: L-glutamic acid, L-Glu
Author keywords: 4-Vinyl pyridine, enantiomer separation, glutamic acid, Surface-molecular imprinting

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