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Authors: Sun Y, Wang B
Article Title: Study on Molecular Recognition Mechanism of Chiral (S)-Ibuprofen's Hydrogen Bonds Self-assembly Imprinted Polymer.
Publication date: 2012
Journal: Chemical Journal of Chinese Universities
Volume: 33
Issue: (4)
Page numbers: 838-842.
Alternative URL: http://www.cjcu.jlu.edu.cn//EN/abstract/abstract24219.shtml
Abstract: Synthesized a series of imprinted polymer by using chiral (S)-ibuprofen with a single polarity group as the template molecular. The calculated results of UV indicated the complex ratio of host-guest was 1:1. The IR analysis revealed in the pre-assembly process and re-adsorption process, the blue-shifted hydrogen bonds and red-shift hydrogen bonds were formed between template molecule and functional monomer, respectively. The isotherm results indicated that the specificity binding capacity was 37.92μmol/g, and the imprinted factor of the polymer was 3.06. The chiral separation experiment indicated that compared with (R)-ibuprofen, (S)-ibuprofen template polymer exhibited significant adsorption selectivity for (S)-ibuprofen. The separation factor was 1.79.
Template and target information: (S)-ibuprofen
Author keywords: Imprinting mechanism, Three-dimensional structure, hydrogen bonds, imprinted factor, (S)-ibuprofen
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