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Reference type: Journal
Authors: Arvand M, Hashemi M
Article Title: Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluids.
Publication date: 2012
Journal: Journal of the Brazilian Chemical Society
Volume: 23
Issue: (3)
Page numbers: 392-402.
DOI: 10.1590/S0103-50532012000300004

Abstract: A potentiometric chemosensor for selective determination of sertraline was developed based on the molecular imprinting technique. The molecularly imprinted polymer was synthesized by precipitation polymerization, using sertraline hydrochloride as a template molecule, methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. The sensor was developed by dispersing the sertraline imprinted polymer particles in dibutyl sebacate plasticizer and embedding in poly(vinyl chloride) matrix. Characteristics of the proposed sensor were evaluated by measuring the potential response to sertraline hydrochloride in the range from 1.0 μmol L -1 to 10 mmol L -1 with a near Nernstian response of 57.7 mV decade-1 and a limit of detection of 0.8 μmol L -1. The potentiometric selectivity coefficients of the proposed sensor were evaluated and it exhibited good selectivity to sertraline with respect to the other antidepressants. It was used as indicator electrode in potentiometric determination of sertraline in tablets and biological fluids. © 2012 Sociedade Brasileira de Química
Template and target information: sertraline
Author keywords: biological fluids, Molecularly imprinted polymers, Potentiometry, precipitation polymerization, Sertraline


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