Abstract: The present work describes an exciting method for the generation of stable silica-molecularly imprinted polymer (MIP) composite fibers, via a non-hydrolytic sol-gel simple route, using carboxylated multiwalled carbon nanotubes. The modified MIP-composite fibers were used as an electrochemical sensor for the selective and sensitive analysis of ultra-trace level of 5-fluorouracil and uracil in aqueous, blood plasma, and pharmaceutical samples. Such sensors could be considered cost-effective, renewable, disposable, and reliable for in-field and clinical studies, without any cross-reactivity and matrix effect from real samples [limit of detection (3 σ, aqueous solution); 1.30 ng mL-1, 5-fluorouracil and 0.56 ng mL-1, uracil].
Template and target information: uracil, 5-fluorouracil
Author keywords: Non-hydrolytic sol-gel, molecularly imprinted polymer, Composite fiber sensor, Uracil and 5-flurouracil, Differential pulse anodic stripping voltammetry