Abstract: A clozapine selective nano-composite carbon paste sensor based on a biomimetic molecular imprinted polymer (MIP) as a sensing element is introduced. The artificial host for clozapine (CLZ) was imprinted based cross-linked polymer. Methacrylic acid (MAA) was used as a functional monomer and chloroform was used as polymerization solvent. Then, nano-composite paste were composed of MIP as a sensing element, multi-walled carbon nanotube (MWCNT), nanosilica (NS), graphite powder, and room temperature ionic liquid (RTIL). The best results were obtained from the nano-composite sensor with the electrode composition of 5% MWCNT, 1% NS, 20% CLZ-MIP, 20% RTIL, and 54% graphite powder. The proposed sensor shows a Nernstian response (28.8±0.3 mV decade-1) in the range of 1.0×10-6-1.0×10-2 mol L-1 with detection limit of 1.0×10-6 mol L-1. The nano-composite based sensor displayed very good selectivity, response time, and specially, lifetime. It was successfully applied in analysis of Clozapine in pharmaceutical formulation.
Template and target information: clozapine, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e]-[1,4]diazepine, CLZ
Author keywords: molecular imprinted polymer (MIP), Clozapine, sensor, Potentiometry, Ionic Liquids, Multi-walled carbon nanotube (MWCNT), Nanosilica (NS)