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Reference type: Journal
Authors: Xin Y, Tong YJ, Yang HL, Zhang L, Zhang YR, Chen Y, Wang W
Article Title: Study on the Glutathione Molecularly Imprinted Polymers with Different Functional Monomers.
Publication date: 2012
Journal: Acta Chimica Sinica
Volume: 70
Issue: (6)
Page numbers: 803-811.

Abstract: Using glutathione (GSH) as template molecule, acrylamide (AM) and methacrylic acid (MAA) as functional monomer, different glutathione-molecularly imprinted polymers (GSH-MIPs) were developed and synthesized with molecularly imprinted technique. The effects for adsorption capacity, including molar ratio of template molecule-functional monomer, pH of loading buffer, adsorption equilibrium time and loading concentration were discussed in detail. The result demonstrated that the polymers with raw material mole ratios at 1 : 5 for GSH : AM, and 1 : 4 for GSH : MAA showed higher adsorption capacity, the optimal pH values for the adsorption of GSH-MIPAMs and GSH-MIPMAAs to GSH were 3.0 and 5.0, respectively; furthermore, the optimal GSH loading concentrations were 1.50 similar to 2.00 g/L for GSH-MIPAMs, and 1.00 similar to 1.50 g/L for GSH-MIPMAAs; additionally, the adsorption equilibrium time was 20 h for GSH-MIPAMs and 18 h for GSH-MIPMAAs. In addition, the binding of GSH analogues were also applied to the synthesized poly-mers, and the results reflected that GSH-MIPs showed low recognition to these analogues. This protocol was further employed for the extraction and separation of GSH from yeast cells samples. The extraction recoveries of GSH-MIPAMs and GSH-MIPMAAs were 41% and 77%, respectively, it was of great potential in the purification of GSH
Template and target information: glutathione, GSH
Author keywords: molecularly imprinting, Glutathione, GSH-MIPs, Preparation, Adsorption conditions, yeast extracts, Adsorption performance


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