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Book title: Molecular and Ionic Recognition with Imprinted Polymers
Editors: Bartsch RA, Maeda M
Publisher: The American Chemical Society
City: Washington DC
Series title: ACS Symposium Series
Volume number: 703

Abstract: "Footprint cavities" are molecular-imprinted sites on an aluminum ion-doped silica gel surface with complementary cavities which also possess Lewis acid sites. Like catalytic antibodies, these sites exhibit catalytic behavior with tailorable selectivity. This distinguishes the footprint cavities from the imprinted adsorption sites in vinyl polymers. These sites catalyze substrate-specific and stereo-selective acyl transfer reactions, condensations, racemizations, and reductions. Our studies of these reactions reveal that the configuration of the template bound during imprinting predetermines the structure of the cavities and the orientation of substrate molecules bound within the cavities determine the mechanisms of the catalyzed reactions. Thus, our investigation of these phenomena provides useful information for the design of templates to allow construction of cavities capable of fine molecular recognition and specific catalysis