MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Moring SE, Wong OS, Stobaugh JF
Article Title: Target specific sample preparation from aqueous extracts with molecular imprinted polymers.
Publication date: 2002
Journal: Journal of Pharmaceutical and Biomedical Analysis
Volume: 27
Issue: (5)
Page numbers: 719-728.
DOI: 10.1016/S0731-7085(01)00495-2

Abstract: In this paper we report a method for the synthesis of molecular imprinted polymers for use in sample preparation with aqueous biological materials. Highly cross-linked bulk polymers were synthesized in the presence of the template molecule, 2,6- pyridinedicarboxylic acid (DPA) using acrylamide (ACD) and 4- vinylpyridine VP) as functional monomers. Conditions are described for the optimization of the template complex with temperature, copolymer mixture and crosslinker type. Selective binding of the template molecule is demonstrated in comparison to structural isomers and analogs for molecular imprinted polymers (MIPs) synthesized with three different crosslinkers, ethyleneglycol dimethacrylate (EGDMA), bisacrylamide and N,N'- 1,3-phenylene bismethacrylamide (PBMA). The chromatographic capacity factors and selectivities for a series of structural analogs were compared. Molecular imprinted polymers prepared with equimolar ratios of ACD and VP and either PBMA or bisacrylamide resulted in highly selective binding for the template versus analogs with similar structure and chemistry. Multiple molecular dissociation constants were measured with the maximum binding capacities for EGDMA, PBMA and bisacrylamide measuring 17, 27 and 90 mumol/g, respectively. (C) 2002 Elsevier Science B.V. All rights reserved


  Periodic table Vindaloo - the chemical formula for curry shirt  Periodic table Bag bag  Meerkat somebody mention coffee mug

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner