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Reference type: Conference Proceeding
Authors: Xiong Y, Huang Y, Ye ZB, Chen C, Zhang ZJ
Publication date: 2012
Article title: Selective Determination of Metformin in Urine Sample Based on Molecularly Imprinted Polymer-Chemiluminescence Sensor.
Page numbers: 798-801
DOI: 10.4028/www.scientific.net/AMR.550-553.798 Alternative URL: http://www.scientific.net/AMR.550-553.798

Proceedings title: Advanced Materials Research
Editors: Liu ZL, Peng F, Liu XG
Publisher: Trans Tech Publications
City: Switzerland
Volume number: 550-553
Conference information: Advances in Chemical Engineering II

Abstract: A flow-injection chemiluminescence (FI-CL) sensor for metformin determination based on recognition materials of molecularly imprinted polymers (MIP) is reported. The sensor was fabricated by packing the MIP particles into a V-shape flow cell. Metformin could be selectively on-line adsorbed by the MIPs and then sensed by its great enhancing effect on the weak CL reaction between N-bromosuccinimide (NBS) and fluorescein. The CL intensity was linear to metformin concentration in the range from 2 x 10-8 to 8 x 10-6 g mL-1 and the limit of detection (L.O.D.) was 6 x 10-9 g mL-1 (3σ). The sensor showed high selectivity, improved sensitivity and excellent stability and reversibility compared with the CL method without using MIPs. The lifetime of the sensor was investigated and MIPs could be reused for more than 200 times. The sensor has been directly applied to determine metformin in human urine.
Template and target information: metformin
Author keywords: Chemiluminescence sensor, flow injection, Metformin Determination, molecularly imprinted polymer


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