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Reference type: Journal
Authors: Mullett WM, Martin P, Pawliszyn J
Article Title: In-tube molecularly imprinted polymer solid-phase microextraction for the selective determination of propranolol.
Publication date: 2001
Journal: Analytical Chemistry
Volume: 73
Issue: (11)
Page numbers: 2383-2389.
DOI: 10.1021/ac0100502

Abstract: A molecularly imprinted polymer (MIP) material was synthesized for use as an in-tube solid-phase microextraction (SPME) adsorbent. The inherent selectivity and chemical and physical robustness of the MIP material was demonstrated as an effective stationary-phase material for in-tube SPME. An automated and on-line MIP SPME extraction method nas developed for propranolol determination in biological fluids. This simplified the sample preparation process and the chromatographic separation of several P-blocker compounds. The method developed for propranolol showed improved selectivity in comparison to alternative in-tube stationary-phase materials, overcoming the limitations of existing SPME coating materials. Preconcentration of the sample by the MIP adsorbent increased the sensitivity, yielding a limit of detection of 0.32 μg/mL by UV detection. Excellent method reproducibility (RSD < 5.0%) and column reusability(> 500 injections) were observed over a fairly wide linear dynamic range (0.5-100 μg/mL) in serum samples. To our knowledge, this is the first report on the automated application of a MIP material for in-tube SPME. The method was inexpensive, simple to set up, and simplified the choice of SPME adsorbent for in-tube extraction. The approach can potentially be extended to other MIPs for the determination of a wide range of chemically significant analytes
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