MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Mullett WM, Martin P, Pawliszyn J
Article Title: In-tube molecularly imprinted polymer solid-phase microextraction for the selective determination of propranolol.
Publication date: 2001
Journal: Analytical Chemistry
Volume: 73
Issue: (11)
Page numbers: 2383-2389.
DOI: 10.1021/ac0100502

Abstract: A molecularly imprinted polymer (MIP) material was synthesized for use as an in-tube solid-phase microextraction (SPME) adsorbent. The inherent selectivity and chemical and physical robustness of the MIP material was demonstrated as an effective stationary-phase material for in-tube SPME. An automated and on-line MIP SPME extraction method nas developed for propranolol determination in biological fluids. This simplified the sample preparation process and the chromatographic separation of several P-blocker compounds. The method developed for propranolol showed improved selectivity in comparison to alternative in-tube stationary-phase materials, overcoming the limitations of existing SPME coating materials. Preconcentration of the sample by the MIP adsorbent increased the sensitivity, yielding a limit of detection of 0.32 μg/mL by UV detection. Excellent method reproducibility (RSD < 5.0%) and column reusability(> 500 injections) were observed over a fairly wide linear dynamic range (0.5-100 μg/mL) in serum samples. To our knowledge, this is the first report on the automated application of a MIP material for in-tube SPME. The method was inexpensive, simple to set up, and simplified the choice of SPME adsorbent for in-tube extraction. The approach can potentially be extended to other MIPs for the determination of a wide range of chemically significant analytes
Template and target information: propranolol


  mipdatabase.com logo imprinters do it in bulk shirt  Mug featuring the name Wayne spelled out in the single letter amino acid code    Shirt featuring the template Propranolol

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner