Book title: Encyclopedia of Biophysics
Editors: Roberts GCK
Series title: Springer Reference
Abstract: Molecular imprinting is the process of template-induced formation of specific recognition sites (binding or catalytic) in a material where the template directs the positioning and orientation of the material's structural components by a self-assembly mechanism. This involves the formation either of a complex (non-covalent imprinting) or reversible covalent bonds (covalent imprinting) between a given target analyte (template) and polymerizable functional monomers dissolved in an appropriate solvent. The template–monomer interactions are then fixed by radical polymerization into the growing polymer network. Subsequent removal of the template leaves binding sites within the polymer that possess both complementary shape and orientation of functional groups to allow selective recognition of the target species.
Template and target information: Review - MIPs