Abstract: To improve the purity of lincomycin A in the crude product, preparation and properties of lincomycin A molecular imprinted polymer microspheres (MIPMs) were studied. Using polystyrene particles as seeds, lincomycin as template molecules, MIPMs were prepared by a single-step swelling and polymerization method. The binding characteristics and molecular recognition of MIPMs were investigated through binding experiments. The results show the MIPMs have the selectivity for lincomycin A, the separation factor between lincomycin A and lincomycin B is 1.27, while the factor is only 1.02 by the non imprinted polymer microspheres (NIPMs). The lincomycin A MIPMs can be used to prepare lincomycin and improve the purity of the crude lincomycin.
Template and target information: lincomycin A
Author keywords: single-step swelling and polymerization method, lincomycin, molecular imprinted polymer microspheres, molecular recognition