Authors: Norell MC
, Andersson HS
, Nicholls IA
Theophylline molecularly imprinted polymer dissociation kinetics: a novel sustained release drug dosage mechanism.
Publication date: 1998
Journal: Journal of Molecular Recognition
Abstract: The template release kinetics of theophylline molecularly imprinted polymers has been examined with a view to determining their potential as a controlled release drug dosage form. The basis for the ligand selectivity of these polymers has been shown through the demonstration of pre-polymerization template-monomer complexation and HPLC studies of the product polymer ligand selectivities, The release kinetics shows a dependence upon template loading and pH. Small differences in release characteristics between imprinted and non- imprinted (reference) polymers have been observed. (C) 1998 John Wiley & Sons, Ltd
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