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Reference type: Journal
Authors: Norell MC, Andersson HS, Nicholls IA
Article Title: Theophylline molecularly imprinted polymer dissociation kinetics: a novel sustained release drug dosage mechanism.
Publication date: 1998
Journal: Journal of Molecular Recognition
Volume: 11
Issue: (1-6)
Page numbers: 98-102.
DOI: 10.1002/(SICI)1099-1352(199812)11:1/6<98::AID-JMR399>3.0.CO;2-Y

Abstract: The template release kinetics of theophylline molecularly imprinted polymers has been examined with a view to determining their potential as a controlled release drug dosage form. The basis for the ligand selectivity of these polymers has been shown through the demonstration of pre-polymerization template-monomer complexation and HPLC studies of the product polymer ligand selectivities, The release kinetics shows a dependence upon template loading and pH. Small differences in release characteristics between imprinted and non- imprinted (reference) polymers have been observed. (C) 1998 John Wiley & Sons, Ltd


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