MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Men JY, Gao BJ, Chen ZP, Yao L
Article Title: Preparation of 5-Fluorouracil-Surface Imprinted Microspheres MIP-PSSS/CPVA and Studies on its Character of Colon-Specific Drug Delivery.
Publication date: 2012
Journal: Acta Chimica Sinica
Volume: 70
Issue: (21)
Page numbers: 2273-2280.
DOI: 10.6023/A12070402
Alternative URL: http://sioc-journal.cn/Jwk_hxxb/EN/abstract/abstract341615.shtml

Abstract: The aim of this work was to investigate the possibility to constitute a conlon-specific drug delivery for 5-fluorouracil (5-FU) by using molecularly imprinted polymers (MIPs) in simulated gastrointestinal fluids, compared to non molecularly imprinted polymers (NMIPs). Surface imprinting of 5-FU was performed on crosslinked polyvinyl alcohol microspheres (CPVA microspheres ) with sodium 4-styrene sulfonate (SSS) as functional monomer and with N,N'-Methylene bisacrylamide (MBA) as crosslinker by using cerium salt-hydroxyl group redox initiation system, and 5-FU-imprinted microspheres MIP-PSSS/CPVA, on which there exists a layer of molecular imprinting, were obtained. The chemical structure and morphology of MIP-PSSS/CPVA microspheres were characterized with infrared spectrum (FTIR) and scanning electron microscope (SEM). The binding property of the imprinted microspheres MIP-PSSS/CPVA for 5-fluorouracil (5-FU), namely drug carrying ability, was mainly investigated and the binding mechanism was explored. The in vitro release behavior of the drug-carried microspheres was also examined. The experimental results show that based on the special cerium salt-hydroxyl group redox initiation system in this investigation, the surface imprinting of 5-FU can be effectively realized, and a polymer layer, in which a lot of 5-FU-imprinted caves are distributed, can be formed on the surfaces of CPVA microspheres. In the acidic medium, the imprinted microspheres MIP-PSSS/CPVA exhibit very strong binding ability for 5-FU by driving of electrostatic interaction. The binding capacity can get up to 105mg/g, displaying the high efficiency of drug carrying. The in vitro release behavior of the drug carrying microspheres not only is highly pH-dependent, but also is time-delayed. The release of pH-dependent is owing to strong electrostatic action between 5-FU molecules and the sulfonate groups in the imprinted caves at low pH. Along with the increase of pH value of the medium, the weakening of the protonation degree of the amino groups of 5-FU, and the electrostatic interaction between MIP-PSSS/CPVA microspheres and 5-FU molecule decreases, leading to the enhancement of 5-FU release. The release of time-delayed coming from the restraining action of the MIP-PSSS/CPVA microspheres for 5-FU, and this binding action is the synergism of strong electrostatic action between 5-FU molecules and the sulfonate groups in the imprinted caves and the 5-FU molecule diffusion resistance caused by the imprinted caves. The experiment results show in the medium of pH=1, the drug does not be released; in the simulated intestine fluid (pH=6.8), the drug release is small; in the simulated colon fluid (pH=7.4), the sudden delivery phenomenon will be produced, displaying an excellent colon-specific drug delivery behavior.
Template and target information: 5-fluorouracil, 5-FU
Author keywords: surface imprinting, Sodium 4-styrene sulfonate, Crosslinked polyvinyl alcohol microspheres, 5-fluorouracil, Colon-specific drug delivery

  Mister Benzene shirt  Chemistry peptide mug  Beach bunny periodic table shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner