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Abstract: The first successfully developed molecularly imprinted polymer toward six ergot alkaloids and their respective epimers is described. A new imprinting molecule, metergoline, was used as template analogue in the production of suspension polymerized beads. These spherical particles functioned as selective sorbent in a solid-phase extraction column. The application of this column in the cleanup of barley samples prior to liquid chromatography coupled with tandem mass spectrometry allowed simple and cost-efficient sample preparation. The performance of the imprinted polymer and a non-imprinted control polymer was evaluated. This includes determination of the recovery values and the matrix effect of each of the 12 tested ergot alkaloids as well as a cross-reactivity study with 25 common mycotoxins. The binding isotherms were obtained for metergoline, thus allowing comparison with other (imprinted) sorbents. A comparison between bulk and suspension polymerization is provided to determine the appropriate production technique
Template and target information: ergot alkaloids, metergoline, ergotamine, Et, ergotaminine, Etn, ergocornine, Eco, ergocorninine, Econ, ergocryptine, Ekr, ergocryptinine, Ekrn, ergocristine, Ecr, ergocristinine, Ecrn, ergosine, Es, ergosinine, Esn, ergometrine, Em, ergometrinine, Emn