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Reference type: Journal
Authors: Xie JQ, Cai CQ, Yang H, Chen XM
Article Title: Synthesis and Application of Molecularly Imprinted Polymer on Selective Solid-Phase Extraction for the Determination of Artemisinin in Artemisia Annua L.
Publication date: 2013
Journal: Analytical Letters
Volume: 46
Issue: (1)
Page numbers: 107-119.
DOI: 10.1080/00032719.2012.706851

Abstract: Molecular imprinted polymer (MIP) was prepared through thermal polymerization by using artemisinin as the template molecule, styrene as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linker, and azobisisobutyronitrile (AIBN) as the initiator. Evaluated by static, kinetic, and bonding capacity adsorption tests, the polymer exhibited a special selective rebinding to artemisinin. Scatchard analysis revealed that two different binding sites were formed in the polymers. The novel imprinted polymer was used as a solid-phase extraction (SPE) sorbent for the extraction of artemisinin from Artemisia annua L., followed by HPLC-UV analysis. The maximum static adsorption capacity of the artemisinin-imprinted sorbent for artemisinin was 8.46 mg g-1.The application of artemisinin-imprinted polymers with high affinity and excellent selectivity toward artemisinin in SPE might offer a novel method for the enrichment and determination of the active ingredient in Chinese medicine
Template and target information: artemisinin
Author keywords: Artemisinin, molecularly imprinted polymer, Solid-phase extraction

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