Abstract: A composite membrane (MIM) molecularly imprinted with S-ibuprofen has been prepared by using a poly(vinylidene fluoride) (PVDF) membrane as supporting membrane, S-ibuprofen as template, acrylamide (AM) as functional monomer, and ethylene glycol dimethacrylate (EGDMA) as cross-linking agent via free radical polymerization. The adsorption and chiral resolution properties of the MIM for racemic ibuprofen were evaluated. The results indicated that the prepared MIM had a certain specific adsorption ability for S-ibuprofen. The adsorption amount increased with increasing ibuprofen concentration from 0.1 to 0.5 mmol/L, but the adsorption selectivity factor decreased from 1.68 to 1.14. The resolution ability of the MIM was evaluated by permeability testing. The permeation amounts of R-ibuprofen and S-ibuprofen were 0.378 and 0.313 μmol/(cm2 h), respectively, and the separation factor could reach 1.21.
Template and target information: S-ibuprofen
Author keywords: S-ibuprofen, molecularly imprinted membrane, Free radical polymerization, chiral resolution