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Reference type: Journal
Authors: Zhao X, Qin PY
Article Title: Preparation and evaluation of molecular imprinted composite membranes for chiral resolution of ibuprofen.
Publication date: 2013
Journal: Journal of Beijing University of Chemical Technology (Natural Science Edition)
Volume: 40
Issue: (1)
Page numbers: 5-9.
Alternative URL:

Abstract: Molecular imprinted membranes of S-ibuprofen were prepared by the phase inversion technique with cellulose acetate-β-cyclodextrin copolymer (P(CA-co-β-CD)). To characterize P(CA-co-β-CD), a biosensor was used to measure its grafting ratio, and P(CA-co-β-CD) polymers with different grafting ratios were used to prepare membranes. A copolymer-DMF solution with a S-ibuprofen template was coagulated in water at 20 C. Increasing P(CA-co-β-CD) grafting ratio resulted in an increase in S-ibuprofen recognition properties of the resulting membrane. The S-ibuprofen imprinted membrane prepared with P(CA-co-β-CD) showed good selectivity to S-ibuprofen. Surface and cross-section morphologies of the membranes were analyzed by scanning electron microscopy. High-performance liquid chromatography was used for the quantification of ibuprofen in the isolated fraction. Under the optimum conditions of β-CD grafting yield of 29.01% (mass fraction), polymer mass fraction of 12.5%, and a concentration ratio of CA to S-Ibu of 1:10, the separation factor reached a maximum value of 2.09.
Template and target information: S-ibuprofen

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