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Reference type: Journal
Authors: Prasad BB, Srivastava A, Tiwari MP
Article Title: Highly sensitive and selective hyphenated technique (molecularly imprinted polymer solid-phase microextraction-molecularly imprinted polymer sensor) for ultra trace analysis of aspartic acid enantiomers.
Publication date: 2013
Journal: Journal of Chromatography A
Volume: 1283
Page numbers: 9-19.
DOI: 10.1016/j.chroma.2013.01.096
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0021967313002185

Abstract: The present work is related to combination of molecularly imprinted solid-phase microextraction and complementary molecularly imprinted polymer-sensor. The molecularly imprinted polymer grafted on titanium dioxide modified silica fiber was used for microextraction, while the same polymer immobilized on multiwalled carbon nanotubes/titanium dioxide modified pencil graphite electrode served as a detection tool. In both cases, the surface initiated polymerization was found to be advantageous to obtain a nanometer thin imprinted film. The modified silica fiber exhibited high adsorption capacity and enantioselective diffusion of aspartic acid isomers into respective molecular cavities. This combination enabled double preconcentrations of d- and l-aspartic acid that helped sensing both isomers in real samples, without any cross-selectivity and matrix complications. Taking into account 6 x 10^4-fold dilution of serum and 2 x 10^3-fold dilution of cerebrospinal fluid required by the proposed method, the limit of detection for l-aspartic acid is 0.031 ng m L-1. Also, taking into account 50-fold dilution required by the proposed method, the limit of detection for d-aspartic acid is 0.031 ng m L-1 in cerebrospinal fluid
Template and target information: aspartic acid
Author keywords: Molecularly imprinted polymer solid-phase microextraction, d- and l-Aspartic acid, Differential pulse anodic stripping voltammetry, Surface grafting-from approach


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