Alternatively for mipdatabase quick searches go here

Custom Search

Abstract: The present work is related to combination of molecularly imprinted solid-phase microextraction and complementary molecularly imprinted polymer-sensor. The molecularly imprinted polymer grafted on titanium dioxide modified silica fiber was used for microextraction, while the same polymer immobilized on multiwalled carbon nanotubes/titanium dioxide modified pencil graphite electrode served as a detection tool. In both cases, the surface initiated polymerization was found to be advantageous to obtain a nanometer thin imprinted film. The modified silica fiber exhibited high adsorption capacity and enantioselective diffusion of aspartic acid isomers into respective molecular cavities. This combination enabled double preconcentrations of d- and l-aspartic acid that helped sensing both isomers in real samples, without any cross-selectivity and matrix complications. Taking into account 6 x 10^4-fold dilution of serum and 2 x 10^3-fold dilution of cerebrospinal fluid required by the proposed method, the limit of detection for l-aspartic acid is 0.031 ng m L-1. Also, taking into account 50-fold dilution required by the proposed method, the limit of detection for d-aspartic acid is 0.031 ng m L-1 in cerebrospinal fluid
Template and target information: aspartic acid
Author keywords: Molecularly imprinted polymer solid-phase microextraction, d- and l-Aspartic acid, Differential pulse anodic stripping voltammetry, Surface grafting-from approach