Authors: Pande VS
, Grosberg AY
, Tanaka T
Thermodynamic procedure to synthesize heteropolymers that can renature to recognize a given target molecule.
Publication date: 1994
Journal: Proceedings of the National Academy of Sciences of the United States of America
Alternative URL: http://links.jstor.org/sici?sici=0027-8424%2819941220%2991%3A26%3C12976%3ATPTSHT%3E2.0.CO%3B2-L
Abstract: We suggest a procedure to synthesize polymers with characteristics similar to those observed in globular proteins: renaturability and the existence of an ''active site'' capable of specifically recognizing a given target molecule. This procedure is investigated by computer simulation, which finds a yield of up to 65%. We believe that, in principle, this scheme can be realized in vitro. The applicability of this approach as a model of prebiotic synthesis in vivo is also discussed
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