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Reference type: Journal
Authors: Meng L, Meng PJ, Zhang QQ, Wang YJ
Article Title: Fast screening of ketamine in biological samples based on molecularly imprinted photonic hydrogels.
Publication date: 2013
Journal: Analytica Chimica Acta
Volume: 771
Page numbers: 86-94.
DOI: 10.1016/j.aca.2013.01.055
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0003267013002031

Abstract: A novel label-free colorimetric chemosensor was developed for handy and fast screening of ketamine with high sensitivity and specificity based on molecularly imprinted photonic hydrogels (MIPHs) that combined the colloidal-crystal with molecular imprinting technique. The unique inverse opal arrays with a thin polymer wall in which the imprinted nanocavities of ketamine moleculars distributed allowed high sensitive, quick responsive, specific detection of the target analyte, and good regenerating ability in an aqueous environment. Due to the hierarchical inverse opal structural characteristics, the specific ketamine molecular recognition process can induce obvious swelling of the MIPHs to be directly transferred into visually perceptible optical signal (change in color) which can be detected by the naked eye through Bragg diffractive shifts of ordered macroporous arrays. In order to enhance the recognition ability in aqueous environments, the MIPHs were designed as water-compatible and synthesized in a water-methanol system. The molecular recognition mechanisms were investigated. The proposed MIPHs were successfully employed to screen trace level ketamine in human urine and saliva samples, exhibiting high sensitivity, rapid response, and specificity in the complex matrix. The smart chemosensor can provide an effective alternative for fast screening of ketamine on the spot for forensic investigations
Template and target information: ketamine
Author keywords: molecularly imprinting, Photonic crystal, Ketamine, chemosensor, Water-phase recognition, biological samples

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