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Reference type: Journal
Authors: Mudiam MKR, Chauhan A, Singh AK, Sharma VP, Saxena PN
Article Title: Molecularly imprinted SPE combined with dispersive liquid-liquid microextraction for selective analysis of telmisartan in biological and formulation samples.
Publication date: 2013
Journal: Bioanalysis
Volume: 5
Issue: (7)
Page numbers: 847-858.
DOI: 10.4155/bio.13.45

Abstract: Background: The present communication describes the combination of molecularly imprinted SPE and dispersive liquid-liquid microextraction for the selective preconcentration and determination of telmisartan (TEL) in rat urine, plasma and pharmaceutical formulation by HPLC. Results: Various factors that can affect the extraction efficiency of molecularly imprinted SPE and dispersive liquid-liquid microextraction were optimized. The LOD and LOQ were found to be 0.19 and 0.63 μg ml-1 in urine, while in plasma it was found to be 0.28 and 0.87 μg ml-1, respectively. The percentage recovery of TEL in different matrices was found to be in the range of 81-97%. Conclusion: The proposed method may find wide applications in clinical, toxicological and QC laboratories for the routine analysis of TEL
Template and target information: telmisartan, TEL


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