MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Zhao JW, Nie L, Zhang LY, Jin Y, Peng Y, Du SH, Jiang N
Article Title: Molecularly imprinted layer-coated silica nanoparticle sensors with guest-induced fluorescence enhancement: theoretical prediction and experimental observation.
Publication date: 2013
Journal: Analytical Methods
Volume: 5
Issue: (12)
Page numbers: 3009-3015.
DOI: 10.1039/C3AY40107C

Abstract: Molecularly imprinted fluorescence sensors operate on the basis of the recognition of imprinted sites to guest and the resultant changes of fluorescence emission have been studied. However, the origin of guest-induced fluorescence enhancement and the function of host molecule are still unclear in theory. In this work, we have first designed three isomers, 2-acrylamidoquinoline, 3-acrylamidoquinoline and 8-acrylamidoquinoline, with weak fluorescence emission, and used them as both functional monomers and signaling units in molecularly imprinted fluorescence sensors. Quantum chemical calculation within the density functional theory (DFT) framework has been introduced to accurately evaluate and predict the hydrogen bonding interaction between these monomers and the analyte melamine. As a result, the as-synthesized 2-acrylamidoquinoline exhibits a highest hydrogen bonding ability and the ideal molar ratio of monomer to template is 3 : 1 in molecularly imprinted polymers, which can greatly enhance the fluorescence emission of functional monomer after guest-host binding due to the strong hydrogen bonding restriction to the transformation of monomer conformations. The prediction is in good agreement with the experimental observation. Moreover, the imprinted nanoparticles display significant fluorescence enhancement upon titration with different concentrations of melamine in methanol. The fluorescence sensors can be applied to detect the melamine in dairy products with a low limit of quantification of 0.5 μM. The results reported herein supply an excellent model for the design of molecularly imprinted fluorescence sensors and their prediction of chemical sensitivity to nonfluorescent compounds
Template and target information: melamine

  mipdatabase.com logo special offer joke shirt  Lab Hunk Periodic shirt  HE-MAN polymer chemistry shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner