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Reference type: Conference Proceeding
Authors: Sun LZ, Sun CJ, Fang YQ, Sun XX
Publication date: 2013
Article title: Synthesis of Nimetazepam - Molecularly Imprinted Polymer and SPE Application.
Page numbers: 200-206
DOI: 10.4028/www.scientific.net/AMR.699.200 Alternative URL: https://www.researchgate.net/publication/269361956_Synthesis_of_Nimetazepam_-_Molecularly_Imprinted_Polymer_and_SPE_Application

Proceedings title: Advanced Materials Research
Editors: Yun J, Zeng DH
Publisher: Trans Tech Publications
City: Switzerland
Volume number: 699
Conference information: Materials Science and Chemical Engineering

Abstract: The synthesis and performance of a molecularly imprinted polymer (MIP) designed to enable the clean-up of the interferences existing in alprazolam (Alpra) drug samples is described. The MIP was synthesized using non-covalent molecularly imprinted method. Nimetazepam (Nimet), which has a similar chemical structure as the major impurities in Alpra drug samples, was used as the dummy template. Methacrylic acid was used as the monomer. Both the affinity and selectivity of the MIP for Nimet and structurally related compounds were examined through batch-rebinding studies. The specific binding amount of Nimet was determined to be 11.4 mg g-1. The MIP was used as the sorbent in solid phase extraction (MI-SPE) and methanol was used as the washing solvent for the clean-up of Nimet in the Alpra complex samples. The effective clean-up of Nimet was achieved, with a recovery > 90% for Alpra, in the stimulated samples.
Template and target information: Nimetazepam, Nimet, dummy template, alprazolam, Alpra
Author keywords: Alprazolam, molecularly imprinted polymer, Nimetazepam, Sample clean-up, Solid-Phase Extraction (SPE), synthesis

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