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Reference type: Journal
Authors: Huangfu FY, Wang B, Shan JJ, Zhang ZL
Article Title: Enantioselective analysis of naproxen using chiral molecular imprinting polymers based thin-layer chromatography.
Publication date: 2013
Journal: E-Polymers
Page numbers: Art No 017.
Alternative URL: http://www.e-polymers.org/journal/abstract.cfm?abstract_Id=5583

Abstract: This paper describes a rational design and testing of molecularly imprinted polymers (MIPs) as chiral stationary phases of thin-layer chromatography (TLC) for enantiomeric purity of naproxen. Using D-naproxen as template, MIPs with particle size between 10 similar to 90 mu m were prepared by precipitation polymerization in acetonitrile/methanol mixed solvent. The interactions between functional monomers and template were verified by UV absorption spectrometry. The morphology, particle size distribution and specific surface area of MIPs were also observed by scanning electron microscopy, particle size distribution meter and liquid nitrogen adsorption instrument, respectively. Binding capacities of MIPs had been studied by equilibrium binding assay. Preparation conditions of TLC and impact of acetic acid content on the separation of enantiomers were investigated. The results indicated that when acetic acid content was 4%, the racemates of templates were completely separated, and the chiral separation factor a was 1.58
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