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Reference type: Journal
Authors: Unceta N, Gómez-Caballero A, García D, Díaz G, Guerreiro A, Piletsky S, Aránzazu Goicolea M, Barrio RJ
Article Title: Enantioselective extraction of (+)-(S)-citalopram and its main metabolites using a tailor-made stir bar chiral imprinted polymer for their LC-ESI-MS/MS quantitation in urine samples.
Publication date: 2013
Journal: Talanta
Volume: 116
Page numbers: 448-453.
DOI: 10.1016/j.talanta.2013.07.004
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0039914013005778

Abstract: This paper reports the application of a chiral imprinted polymer (CIP)-coated stir bar for the selective extraction of (+)-(S)-citalopram (SCIT) and its main metabolites, (+)-(S)-desmethylcitalopram (SDCIT) and (+)-(S)-didesmethylcitalopram (SDDCIT), from urine samples. The developed device has been demonstrated to be capable of selectively extracting the three target analytes from urine samples without saturating the imprinted sites. A CIP-coated stir bar sorptive extraction procedure (CIP-SBSE) is proposed for the isolation of SCIT, SDCIT and SDDCIT followed by their subsequent analysis using liquid chromatography ion trap mass spectrometry (LC-ITMS). Deuterated SCIT-d6 was used as an internal standard. The method was validated using a standard procedure, which revealed that a quantification of 5 ng mL-1 was obtained in urine samples and that the accuracy and precision were within the established values while no matrix effect was observed
Template and target information: (+)-(S)-citalopram, SCIT, (+)-(S)-desmethylcitalopram, SDCIT, (+)-(S)-didesmethylcitalopram, SDDCIT, citalopram
Author keywords: S-citalopram, S-desmethylcitalopram, S-didesmethylcitalopram: chiral imprinted polymer (CIP)-coated stir bar, LC-ESI-ITMS, urine


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