MIPs logo MIPdatabase      Special issue call for papers   
Custom Search
Reference type: Journal
Authors: Dramou P, Zuo PL, He H, Pham-Huy LA, Zou WY, Xiao D, Pham-Huy C, Ndorbor T
Article Title: Anticancer loading and controlled release of novel water-compatible magnetic nanomaterials as drug delivery agents, coupled to a computational modeling approach.
Publication date: 2013
Journal: Journal of Materials Chemistry B
Volume: 1
Issue: (33)
Page numbers: 4099-4109.
DOI: 10.1039/C3TB20502A

Abstract: The preparation, characterization and application of novel anticancer "epirubicin" (EPI) water-compatible magnetic molecularly imprinted polymers (M-MIPs) like artificial antibodies by computational design and chemical synthesis as a carrier for drug delivery is described herein. Two monomers: methacrylic acid (MAA) and methacrylamide (MAM) were selected by computational simulation from the four chemicals used. Covalent and non-covalent bonds were evaluated by this technique based on the interaction mode and energy with template or solvent. Non-covalent bonding was predominant in all cases and major energy interaction was observed. The nanomaterials were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), and a vibrating sample magnetometer (VSM). The loading and controlled release studies performed showed a slight advantage for the M-MIP obtained from MAA than that from MAM at ambient temperature. However, the drug release in vitro was slightly better for the second M-MIP when the temperature increased to 50 C. The water-compatible nanomaterial showed good pH-sensitive drug release profiles in vitro. Briefly, due to its magnetic property, amphiphilicity, good biomimetic recognition of EPI, high adsorption capacity and controlled release, the epirubicin M-MIPs synthesized in this study are suitable to be applied to a magnetic targeted drug delivery system
Template and target information: epirubicin, EPI

  I love MISPE shirt  multi MIPs logo mug  British periodic table patriotic tote bag


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner