Paper 9495

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Reference type: Conference Proceeding
Authors: Lebal N, Hallil H, Dejous C, Plano B, Krstulja A, Delepee R, Rebiere D, Agrofoglio LA
Publication date: 2013
Article title: Association of a Love wave sensor to thin film molecularly imprinted polymers for nucleosides analogs detection.
Page numbers: 550-553
DOI: 10.1109/NEMS.2013.6559790

ISBN: ISBN: 978-146736352-5

Abstract: The overall objective of this work is to develop and validate a quantitative, non-invasive therapeutic tool to detect selected urinary modified nucleosides as biomarkers of colorectal cancer chemotherapy and to monitor in fine the efficiency of the chemotherapy. Our methodology takes the advantage of high sensitivity of acoustic biosensor combined with high selectivity and robustness of thin molecularly imprinted polymer (MIP) film. In this paper we present a process based on a thin film of a MIP of adenosine 5'-monophosphate (AMP) coating on the sensor surface which is compatible with the acoustic wave propagation. Detection tests of AMP have been performed in aqueous media. The sensor response was recorded in terms of synchronous frequency and total insertion losses after both steps: extraction from, rebinding by the MIP layer. A frequency decrease of 6,875 Hz was recorded for 25μg/mL AMP concentration. � 2013 IEEE
Template and target information: adenosine 5'-monophosphate, AMP
Author keywords: AMP detection, cancer biomarkers, Love wave sensor, thin film molecularly imprinted polymer

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