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Reference type: Journal
Authors: Piletska E, Kumire J, Sergeyeva T, Piletsky S
Article Title: Rational design and development of affinity adsorbents for analytical and biopharmaceutical applications.
Publication date: 2013
Journal: Journal of the Chinese Advanced Materials Society
Volume: 1
Issue: (3)
Page numbers: 229-244.
DOI: 10.1080/22243682.2013.839207

Abstract: With increased level of regulations and growing consumer awareness, there is a big demand for bioactive compounds that are sourced from sustainable, natural/biological feedstocks. These chemicals have potential application in pharmaceutical, cosmetic and nutraceuticals sectors. However, design and selection of selective adsorbents for chemically diverse chemical and biological compounds from complex matrix is a very challenging task. There is a strong call for a larger diversity of the custom-made extraction adsorbents which would facilitate the extraction and purification of natural and synthetic compounds for the nutraceutical and pharmaceutical industries. Equally important is an application of affinity adsorbents and membranes in bioanalytical applications where processing of analytical samples still remains an issue. Among the main requirements for these adsorbents is their specificity, high binding capacity, short time of preparation, low cost and high stability. This paper shows how computational approach can help producing the polymeric materials possessing the required properties quickly and effectively. The design and development strategies have been outlined, analyzed, and illustrated by the examples of recent successes in the computational design of the polymeric adsorbents and membranes
Template and target information: Review - affinity sorbents
Author keywords: affinity adsorbents, Molecularly imprinted polymers, membranes, separation, purification


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