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Reference type: Book Chapter
Authors: Yuan H, Zhang L, Zhang Y
Publication date: 2012
Chapter title: 2.18 - Monoliths, Fundamentals for Sample Preparation.
Chapter number: 18
Page numbers: 345-358.
DOI: 10.1016/B978-0-12-381373-2.00052-1 Alternative URL: http://www.sciencedirect.com/science/article/pii/B9780123813732000521

Book title: Comprehensive Sampling and Sample Preparation
Editors: Pawliszyn J
Publisher: Academic Press
City: Oxford
ISBN: 978-0-12-381374-9
Volume number: 2

Abstract: The focus of this chapter is on the development of various monoliths for sample preparation, including polymer monoliths, silica monoliths, and organic-silica hybrid monoliths. The properties of various monolithic materials and the application fields are discussed. Furthermore, chemical modifications of the monolith surface and its effects on sample pretreatment efficiency are reviewed. The applications of monolithic materials for biomolecule analysis, drug analysis, and environmental sample analysis are discussed, with significant focus on the hyphenation of monolith-based sample preparation with separation and detection techniques. Furthermore, the potential trend for the development of multi-dimensional analytical systems with online monolith-based microextraction techniques is discussed
Author keywords: Bio-macromolecule analysis, drug analysis, environmental analysis, Hybrid monolith, microextraction, molecular imprinted monolith, polymer monolith, Silica monolith, surface modification

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