Abstract: A sensitive chlorpromazine sensor based on molecularly imprinted membrane(MIP) was fabricated with chlorpromazine as template molecule and o-aminophenol as functional monomers. The performance of MIP and the electrochemical behavior of molecular imprinted sensor were obtained by cyclic voltammetry(CV) and differential pulse voltammetry(DPV). The sensor exhibited good selectivity and sensitivity for measuring chlorpromazine compared with the structurally-related compounds of promethazine and perphenazine. The linear relationship between the peak current and chlorpromazine concentration is found at the range of 6.0 x 10-7 ~ 9.0 x 10-5 mol/L, the liner equation is I(μA) = 61.25lg c(μmol/L) +23.47 (r=0.9975), the limit of detection is 2.0 x 10-7 mol/L. This sensor has many advantages such as high sensitivity, good reproducibility and repeatability.
Template and target information: chlorpromazine
Author keywords: Chlorpromazine, molecularly imprinting, Electrochemical sensor, electropolymerization