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Reference type: Journal
Authors: Zengin A, Yildirim E, Tamer U, Caykara T
Article Title: Molecularly imprinted superparamagnetic iron oxide nanoparticles for rapid enrichment and separation of cholesterol.
Publication date: 2013
Journal: Analyst
Volume: 138
Issue: (23)
Page numbers: 7238-7245.
DOI: 10.1039/C3AN01458D

Abstract: A general protocol to prepare surface molecularly imprinted polymer core-shell superparamagnetic Fe3O4 nanoparticles (Fe3O4@MIP SPNPs), using a surface-mediated RAFT polymerization approach, is described. Cholesterol-imprinted Fe3O4@MIP SPNPs were obtained by oleic acid-stabilized Fe3O4 nanoparticles with a trithiocarbonate agent and subsequently by polymerizing thin molecularly imprinted layers composed of dimethylacrylamide and N,N'-methylene(bis)acrylamide units. The surface-mediated RAFT polymerization approach allows the synthesis of ~20 nm hybrid composite particles with a ~6 nm MIP shell, exhibiting superparamagnetic properties (saturation magnetization = 35.4 emu g-1) and specific molecular recognition of cholesterol. The Fe3O4@MIP SPNPs show the capability of rapid enriching and separating cholesterol (~3.1% in weight) and are renewable and cyclically exploited due to their monodispersive and superparamagnetic features. Moreover, under optimal conditions, the Fe3O4@MIP SPNP recoveries of spiked human serum, milk, yolk and beef were 91.6%, 93.6%, 92.4% and 91.2%, respectively. Finally, the method of molecular imprinting on superparamagnetic particles can be extended to a wide range of applications for cell sorting, biomolecule enrichment and separation, and drug delivery
Template and target information: cholesterol


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